The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins.

نویسندگان

  • V Ollendorff
  • T Noguchi
  • O deLapeyriere
  • D Birnbaum
چکیده

We have characterized a new human gene, named GARP, localized in the 11q14 chromosomal region. GARP comprises two coding exons, is expressed as two major transcripts of 4.4 and 2.8 kilobases, respectively, and encodes a putative transmembrane protein of 662 amino acids, the extracellular portion of which is almost entirely made of leucine-rich repeats. The molecular weight of the protein immunoprecipitated from transfected cells is 80,000. The GARP protein has structural similarities with the human GP Ib alpha and GP V platelet proteins, and with the Chaoptin, Toll, and Connectin adhesion molecules of Drosophila.

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عنوان ژورنال:
  • Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research

دوره 5 2  شماره 

صفحات  -

تاریخ انتشار 1994